Efficacy of leukemia inhibitory factor in experimental autoimmune neuritis.

Autor(es): Laurà M.; Gregson N. A.; Curmi Y.; Hughes R. A. C.

Resumo: Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that exerts neurotrophic and myotrophic actions. We have investigated the effect of LIF in experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome (GBS). Treatment with LIF at the onset of the disease showed a slight, but not significant, improvement in the clinical course but no effect on nerve histology.

Imprenta: Journal of Neuroimmunology, v. 133, n. 1-2, p. 56-59, 2002

Identificador do objeto digital: 10.1016/S0165-5728(02)00359-4

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Clinical examination ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2002