Detection of diphtheritic polyneuropathy by acute flaccid paralysis surveillance, India

Autor(es): Mateen Farrah J,Bahl Sunil,Khera Ajay,Sutter Roland W

Resumo: Diphtheritic polyneuropathy is a vaccine-preventable illness caused by exotoxin-producing strains of Corynebacterium diphtheriae. We present a retrospective convenience case series of 15 children (6 girls)<15 years of age (mean age 5.2 years, case-fatality rate 53%, and 1 additional case-patient who was ventilator dependent at the time of last follow-up; median follow-up period 60 days) with signs and symptoms suggestive of diphtheritic polyneuropathy. All cases were identified through national acute flaccid paralysis surveillance, which was designed to detect poliomyelitis in India during 2002-2008. We also report data on detection of diphtheritic polyneuropathy compared with other causes of acute flaccid paralysis identified by this surveillance system.

Palavras-Chave: Corynebacterium diphtheriae; Guillain-Barré syndrome; India; Acute flaccid paralysis surveillance system; Bacteria; Diphtheria; Diphtheritic polyneuropathy; Immunization; Neurology; Paralysis

Imprenta: Emerging Infectious Diseases, v. 19, n. 9, p. 1368-1378, 2013

Identificador do objeto digital: 10.3201/eid1909.130117

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Vaccine ; Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Public health

Data de publicação: 2013