Current proposed mechanisms of action of intravenous immunoglobulins in inflammatory neuropathies

Autor(es): Jacob Saiju,Rajabally Yusuf A

Resumo: Intravenous immunoglobulins (IVIg) have been shown in a number of trials, to be an effective treatment for the three main types of inflammatory neuropathies: Guillain-Barré Syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system including B-cells, T-cells, macrophages, complement, cytokines and cellular adhesion molecules. This article reviews the published evidence and the principal postulated mechanisms of action of intravenous immunoglobulins with special emphasis on inflammatory neuropathies.

Palavras-Chave: Chronic inflammatory demyelinating polyneuropathy; Guillain Barre syndrome; Intravenous immunoglobulins; Inflammatory neuropathy; Mechanisms of action; Multifocal motor neuropathy

Imprenta: Current Neuropharmacology, v. 7, n. 4, p. 337-342, 2009

Identificador do objeto digital: 10.2174/157015909790031166

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytokines

Data de publicação: 2009