Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study

Autor(es): Gill Liza,Zarbo Allison,Isedeh Prescilia,Jacobsen Gordon,Lim Henry W,Hamzavi Iltefat

Resumo: Few large-scale studies have quantified the burden of comorbid autoimmune diseases in patients with vitiligo. We sought to determine the prevalence of comorbid autoimmune diseases in patients with vitiligo. We conducted a manual chart review on a cohort of 1873 patients with vitiligo seen between January 2002 and October 2012 at the Henry Ford Health System in Detroit, MI. Patients were excluded if they had fewer than 2 dermatology notes (N = 595) or if they were never given a diagnosis of vitiligo by a dermatologist (N = 180). Of 1098 patients with vitiligo, nearly 20% had at least 1 comorbid autoimmune disease. Compared with the general US population, we found a higher prevalence of thyroid disease (12.9%, P < .001), alopecia areata (3.8%, P < .001), inflammatory bowel disease (0.9%, P = .046), pernicious anemia (0.5%, P = .007), systemic lupus erythematosus (0.3%, P = .048), Guillain-Barre syndrome (0.3%, P < .001), discoid lupus (0.2%, P = .003), linear morphea (0.2%, P < .001), myasthenia gravis (0.2%, P = .002), and Sjögren syndrome (0.2%, P = .011). The study lacked a control group. This was a single-institution study with possible selection bias, and thus the findings may not be representative of the overall population of patients with vitiligo. We observed a high prevalence of comorbid autoimmune diseases in patients with vitiligo and report several new associations.

Palavras-Chave: Alopecia areata; Associations; Autoimmune disease; Comorbidities; Prevalence; Thyroid disease; Vitiligo

Imprenta: Journal of the American Academy of Dermatology, v. 74, n. 2, p. 295-302, 2016

Identificador do objeto digital: 10.1016/j.jaad.2015.08.063

Descritores: Guillain-Barre Syndrome - Public health

Data de publicação: 2016