Cluster of atypical adult Guillain-Barré syndrome temporally associated with neurological illness due to EV-D68 in children, South Wales, United Kingdom, October 2015 to January 2016
Autor(es): Williams Christopher J,Thomas Rhys H,Pickersgill Trevor P,Lyons Marion,Lowe Gwen,Stiff Rhianwen E,Moore Catherine,Jones Rachel,Howe Robin,Brunt Huw,Ashman Anna,Mason Brendan W
Resumo: We report a cluster of atypical Guillain-Barré syndrome in 10 adults temporally related to a cluster of four children with acute flaccid paralysis, over a 3-month period in South Wales, United Kingdom. All adult cases were male, aged between 24 and 77 years. Seven had prominent facial diplegia at onset. Available electrophysiological studies showed axonal involvement in five adults. Seven reported various forms of respiratory disease before onset of neurological symptoms. The ages of children ranged from one to 13 years, three of the four were two years old or younger. Enterovirus testing is available for three children; two had evidence of enterovirus D68 infection in stool or respiratory samples. We describe the clinical features, epidemiology and state of current investigations for these unusual clusters of illness.
Palavras-Chave: Acute flaccid paralysis; Guillain-Barré Syndrome; Miller Fisher syndrome; Enterovirus
Imprenta: Euro surveillance : European Communicable Disease Bulletin, v. 21, n. 4, p. 26-32, 2016
Identificador do objeto digital: 10.2807/1560-7917.ES.2016.21.4.30119
Descritores: Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Public health
Data de publicação: 2016
