Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome
Autor(es): Cats Elisabeth A,van der Pol W-Ludo,Tio-Gillen Anne P,Diekstra Frank P,van den Berg Leonard H,Jacobs Bart C
Resumo: Multifocal motor neuropathy (MMN) and the Guillain-Barré syndrome (GBS) are immune-mediated motor neuropathies with antibodies against the ganglioside GM1. In GBS, these antibodies are induced by molecular mimicry, but in MMN their origin is elusive. We compared the light-chain use of anti-GM1 IgM antibodies in serum from 42 patients with MMN and 23 patients with GBS by ELISA. Exclusive use of either ? or ? light chains was found in 38 (90%) patients with MMN and 9 (39%) with GBS (p<0.001). Anti-GM1 IgM antibodies in most patients with MMN are produced by only a single or very limited number of B-cell clones, whereas in most patients with GBS, anti-GM1 IgM antibodies are most likely polyclonal.
Palavras-Chave: Guillain-Barre syndrome; Neuropathy
Imprenta: Journal of Neurology, Neurosurgery, and Psychiatry, v. 86, n. 5, p. 502-504, 2015
Identificador do objeto digital: 10.1136/jnnp-2014-308118
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Molecular methods ; Guillain-Barre Syndrome - Immunology ; Guillain-Barre Syndrome - Public health
Data de publicação: 2015
