Campylobacter jejuni--microtubule-dependent invasion.

Autor(es): Kopecko D J,Hu L,Zaal K J

Resumo: Campylobacter jejuni is the leading bacterial cause of food-borne illness worldwide and a major cause of Guillain-Barré paralysis. Recent molecular and cellular studies of one well-characterized C. jejuni strain have begun to unravel the details of an unusual microtubule-dependent (actin-filament-independent) gut-invasion mechanism, through which at least some C. jejuni initiate disease. Although responsible for causing a human dysenteric syndrome remarkably similar to that triggered by Shigella spp., current evidence suggests that C. jejuni use some markedly different molecular mechanisms of pathogenesis compared with shigellae.

Imprenta: Trends in Microbiology, v. 9, n. 8, p. 389-396, 2001

Identificador do objeto digital: 10.1016/S0966-842X(01)02107-2

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis

Data de publicação: 2001