AUY954, a selective S1P(1) modulator, prevents experimental autoimmune neuritis.

Autor(es): Zhang Zhi-Yuan,Zhang Zhiren,Zug Caroline,Nuesslein-Hildesheim Barbara,Leppert David,Schluesener Hermann J

Resumo: Experimental autoimmune neuritis (EAN) is a T cell-mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system and an animal model of human inflammatory demyelinating polyradiculoneuropathy. AUY954, which targets selectively the sphingosine-1-phosphate receptor 1 (S1P(1)), is known to sequester lymphocytes into secondary lymphoid tissues. In EAN rats, AUY954 greatly prevented paraparesis if administrated from the day of immunization. T cell, B cell, and macrophage infiltration, inflammatory demyelination, and local expression of interleukine-17 and matrix metalloproteinase-9 in sciatic nerves of EAN rats were significantly decreased by AUY954 treatment. Therefore, S1P(1) modulation might be a potential treatment option for inflammatory neuropathies.

Imprenta: Journal of Neuroimmunology, v. 216, n. (1-2), p. 59-65, 2009

Identificador do objeto digital: 10.1016/j.jneuroim.2009.09.010

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2009