Acute-onset chronic inflammatory demyelinating polyneuropathy with focal segmental glomerulosclerosis.
Autor(es): Quek Amy May Lin,Soon Derek,Chan Yee Cheun,Thamboo Thomas Paulraj,Yuki Nobuhiro
Resumo: Inflammatory neuropathies have been reported to occur in association with nephrotic syndrome. Their underlying immuno-pathogenic mechanisms remain unknown. A 50-year-old woman concurrently presented with acute-onset chronic inflammatory demyelinating polyneuropathy and nephrotic syndrome secondary to focal segmental glomerulosclerosis. Both neuropathy and proteinuria improved after plasma exchange and steroids. Literature review of cases of concurrent inflammatory neuropathies and nephrotic syndrome revealed similar neuro-renal presentations. This neuro-renal condition may be mediated by autoantibodies targeting myelin and podocytes.
Palavras-Chave: Autoimmune disease, Chronic inflammatory demyelinating polyneuropathy, Focal segmental glomerulosclerosis, Guillain-Barré syndrome, Nephrotic syndrome, Peripheral neuropathy
Imprenta: Journal of the Neurological Sciences, v. 341, n. 1-2, p. 139-143, 2014
Identificador do objeto digital: 10.1016/j.jns.2014.03.040
Descritores: Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis
Data de publicação: 2014
