Acute oropharyngeal palsy is associated with antibodies to GQ1b and GT1a gangliosides.

Autor(es): O'Leary C P,Veitch J,Durward W F,Thomas A M,Rees J H,Willison H J

Resumo: Three patients with acute oropharyngeal palsy had high titre anti-GQ1b and anti-GT1a IgG antibodies. No patients had ophthalmoplegia or ptosis. In all patients limb ataxia or areflexia were present without notable limb weakness. These patients describe an oropharyngeal variant of Guillain-Barré syndrome in terms of anti-GQ1b antibody reactivity and show that high titre anti-GQ1b antibodies, serologically indistinguishable from those found in Miller Fisher syndrome, can occur in a clinical setting without ophthalmoplegia. The anti-GQ1b and anti-GT1a antibody assays may be helpful tests when considering the differential diagnosis of acute oropharyngeal palsy.

Imprenta: Journal of Neurology, Neurosurgery, and Psychiatry, v. 61, n. 6, p. 649-651, 1996

Identificador do objeto digital: 10.1136/jnnp.61.6.649

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 1996