Acute bulbar, neck and limb weakness with monospecific anti-GT1a antibody: A rare localized subtype of Guillain-Barré sydnrome.

Autor(es): Garg Nidhi,Yuki Nobuhiro,Park Susanna B,Barnett Michael H,Kiernan Matthew C

Resumo: Acute bulbar, neck, and limb weakness carries several potential differential diagnoses. Although a diagnosis can often be established clinically, investigations such as electrodiagnostic and antibody testing can provide support for the clinical diagnosis and may aid in understanding the pathogenesis. A 65-year-old woman presented with acute bulbar, neck, and rapidly progressive bilateral upper limb weakness. Clinical evaluation, electrophysiological, and serological studies were undertaken. Neurophysiology demonstrated proximal conduction block. A clinical diagnosis of pharyngeal-cervical-brachial weakness, a localized variant of Guillain-Barré syndrome, was made. The patient received treatment with intravenous immunoglobulin and made a remarkable recovery over the next month. She was found to have serum monospecific anti-GT1a antibodies. We report a case of pharyngeal-cervical-brachial weakness with monospecific anti-GT1a antibodies and discuss the differential diagnosis of acute bulbar, neck, and limb weakness. Muscle Nerve 53: 143-146, 2016.

Palavras-Chave: Guillain-Barré, anti-ganglioside antibodies, clinical neurophysiology, immunology, pharyngeal-cervical-brachial weakness, syndrome

Imprenta: Muscle & Nerve, v. 53, n. 1, p. 143-146, 2016

Identificador do objeto digital: 10.1002/mus.24935

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Serological diagnosis ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2016