The role of integrins in immune-mediated diseases of the nervous system

Autor(es): Archelos J J,Previtali S C,Hartung H P

Resumo: Immune-mediated diseases of the CNS and PNS, such as multiple sclerosis and Guillain-Barré syndrome, respectively, constitute a major cause of transient and permanent neurological disability in the adult. The aetiology and pathogenesis of these disorders are only partially understood. On a cellular level, focal mononuclear-cell infiltration with demyelination and eventual axonal loss is a crucial pathogenetic event that leads to inflammation and subsequent dysfunction. Here, the evidence that integrins, a family of cell adhesion molecules, expressed on neural and immune cells might play a central role in immune cell recruitment to the CNS and PNS, and probably in tissue repair is reviewed. Distinct integrin expression patterns are observed in multiple sclerosis and Guillain-Barré syndrome. Therapeutic targeting of integrins has been very successful in the corresponding animal models and holds promise as a novel treatment strategy to combat human immune-mediated disorders of the nervous system.

Palavras-Chave: Neuroscience; Cell biology; Developmental biology; Immunology; Integrins; Inflammation; EAE; EAN; Multiple sclerosis; Guillain-Barré; Therapy

Imprenta: Trends in Neurosciences, v. 22, n. 1, p. 30-38, 1999

Identificador do objeto digital: 10.1016/S0166-2236(98)01287-9

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Inflammation

Data de publicação: 1999