The acute paralysis in Guillain-Barré syndrome is related to a Na+ channel blocking factor in the cerebrospinal fluid

Autor(es): Brinkmeier H,Wollinsky K H,Hülser P J,Seewald M J,Mehrkens H H,Kornhuber H H,Rüdel R

Resumo: The effect of cerebrospinal fluid (CSF) from patients with severe polyradiculoneuritis (Guillain-Barré syndrome, GBS) on voltage-dependent Na+ channels of myoballs was studied. The transient Na+ currents, elicited by repetitive stimulation at 1 Hz, were inhibited by the CSF from most of the GBS patients to 10%-40% the control value. The inhibition was complete in about 5 s and was fully reversible. Such inhibition was never seen with control CSF. The blocking property of the CSF from GBS patients was lost after the number of cells and the protein content had been lowered by means of a clinical filtration technique for cerebrospinal fluid. The results demonstrate that in Guillain-Barré syndrome blocking factors of Na+ channels are present in the CSF, impairing neuron impulse conduction, and thereby causing muscular weakness and sensory disturbances in the affected patient.

Palavras-Chave: Guillain-Barré syndrome; Autoimmune disorder; Cerebrospinal fluid; Sodium channels; Whole-cell recording

Imprenta: Pflu?gers Archiv : European journal of physiology, v. 421, n. 6, p. 552-557, 1992

Identificador do objeto digital: 10.1007/BF00375050

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Proteins

Data de publicação: 1992