Locked-in syndrome in three children with Guillain-Barré syndrome.
Autor(es)Medici Conrado; Gonzalez Gabriel; Cerisola Alfredo; Scavone Cristina
ResumoLocked-in syndrome is a rare disorder in childhood. It resembles brain death, but patients are fully conscious, and incapable of communicating because of the complete paralysis of voluntary muscles. Although it can be caused by Guillain-Barré syndrome, it is rarely reported in pediatrics. We describe three pediatric cases of locked-in syndrome in patients with Guillain-Barré syndrome presenting acute tetraplegia, areflexia, cranial nerve involvement, and albuminocytologic dissociation in the cerebrospinal fluid. Electrophysiologic studies indicated acute motor axonal polyradiculoneuropathy in one patient, and acute motor sensory axonal polyradiculoneuropathy in the other two. Most Guillain-Barré syndrome patients with locked-in syndrome demonstrate nerve inexcitability in neurophysiologic studies, poor clinical outcomes, and increased risk of sequelae.
ImprentaPediatric Neurology, v. 45, n. 2, p. 125-128, 2011
Identificador do Objeto Digital10.1016/j.pediatrneurol.2011.03.005
DescritoresGuillain-Barre Syndrome - Pathogenesis
Data de Publicação:2011
