Immune-mediated peripheral neuropathies and voltage-gated sodiums channels.
Autor(es): Benatar M.; Willison H. J.; Vincent A.
Resumo: Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barré syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cells.
Imprenta: Muscle & Nerve, v. 22, n. 1, p. 108-110, 1999
Identificador do objeto digital: 10.1002/(SICI)1097-4598(199901)22:1<108::AID-MUS16>3.0.CO;2-
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology
Data de publicação: 1999
