Platelet cold agglutinins and thrombocytopenia: A diagnostic dilemma in the intensive care unit.
Autor(es): Kumar Tv Bharath; Bhardwaj Neerja
Resumo: We report a case of pseudo-thrombocytopenia due to cold agglutinins against platelets. These cold agglutinins were the cause for diagnostic confusion and resulted in extensive workup and unnecessary therapeutic precautions. A thirty two year old female with Guillain-Barre syndrome was admitted in the ICU and serial work-up showed markedly low levels of platelets. The patient had no symptoms of bleeding and patient was investigated extensively for deciphering the etiology of low platelet count. In-vitro clumping of platelets was suspected and in-vitro studies showed marked clumping of platelets with ethylene-diamine-tetra-acetic acid, citrate and heparinized samples. The manual platelet count was found to be within normal limits. Thrombocytopenia as a result of platelet cold agglutinins is a rare cause of in-vitro low platelet counts. No clinical problems have been reported due to the same.
Palavras-Chave: Cryoagglutinins (cold agglutinins), intensive care units, thrombocytopenia
Imprenta: Journal of Anaesthesiology, Clinical Pharmacology, v. 30, n. 1, p. 89-90, 2014
Identificador do objeto digital: 10.4103/0970-9185.125711
Descritores: Guillain-Barre Syndrome - Pathogenesis
Data de publicação: 2014
