A case of multiple cranial neuropathy with positive antinuclear antibody responded to steroid

Autor(es): Ogawa K,Saruya T,Mochizuki Y,Oishi M,Takasu T


Resumo: A 56-year-old woman was admitted to our hospital because of bilateral ptosis, total ophthalmoplegia, bilateral facial palsy and left hypoglossal nerve palsy. Antinuclear antibody (ANA) showed high titer of 1280 but other data were normal. With oral prednisolone therapy (40 mg/day), the symptoms improved gradually but ANA titer did not show any significant change. We thought multiple cranial neuropathy of the patient was due to autoimmune disease such as collagen disease or cranial nerve type of Guillain-Barré syndrome from her symptoms and positive ANA. In contrast to other reported cases of multiple cranial neuropathy with positive ANA, in our patient ANA titer was high, only motor cranial nerves were impaired, and total ophthalmoplegia was found. Steroid therapy was useful in accordance with other reports. Although our patient has no symptoms related to collagen diseases, a long follow-up of this patient is considered to be necessary.


Palavras-Chave: Multiple cranial neuropathy; Antinuclear antibody; Steroid therapy


Imprenta: No? to Shinkei = Brain and Nerve, v. 52, n. 5, p. 407-411, 2000


Identificador do objeto digital: 10.11477/mf.1406901596


Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology


Data de publicação: 2000