Autor(es): Mavale Mangala, Parashar Deepti, Sudeep Anakkathil, Gokhale Mangesh, Ghodke Youwaraj, Geevarghese Geevarghese, Arankalle Vidya, Mishra Akhilesh Chandra

Resumo: Experiments were conducted to demonstrate the role of male Aedes aegypti mosquitoes in the maintenance - transmission of chikungunya virus (CHIKV) to female mosquitoes. We demonstrated that infected male mosquitoes are capable of infecting females during mating. The infection rate in female mosquitoes was 11% when virgin female mosquitoes were allowed to coinhabit with infected males. The body suspension of venereally infected female mosquitoes induced illness in infant Swiss albino mice, which demonstrated the infectivity of the venereally transmitted virus. The presence of CHIKV in the brains of the ill mice was confirmed by a reverse transcription-polymerase chain reaction specific for partial sequences of nonstructural protein 4 - envelope 1 genes. In the light of the recent report of transovarial transmission of CHIKV in mosquitoes, although at a lower level, this finding has significance because it may help in transmission of the virus to females venereally to start a new infection cycle.

Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 83, n. 6, p. 1242-1244, 2010

Identificador do objeto digital: 10.4269/ajtmh.2010.09-0577

Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Public health

Data de publicação: 2010

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