Trigocherrin A, the first natural chlorinated daphnane diterpene orthoester from Trigonostemon cherrieri
Autor(es): Allard Pierre-Marie, Martin Marie-Thérèse, Dau Marie-Elise Tran Huu, Leyssen Pieter, Guéritte Françoise, Litaudon Marc
Resumo: Trigocherrin A, a chlorinated - highly oxygenated daphnane diterpenoid orthoester (DDO), was isolated from the bark of Trigonostemon cherrieri. Trigocherrin A is the first example of a naturally occurring halogenated DDO. Its structure was elucidated by comprehensive analysis of NMR spectroscopic data, - its absolute configuration was determined by comparison of experimental - theoretically calculated ECD spectra. Trigocherrin A exhibited a potent - selective effect against Chikungunya virus in Vero cells.
Imprenta: Organic Letters, v. 14, n. 1, p. 342-345, 2012
Identificador do objeto digital: 10.1021/ol2030907
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Molecular structure ; Chikungunya Virus - Virus
Data de publicação: 2012
