Autor(es)Allard Pierre-Marie, Martin Marie-Thérèse, Dau Marie-Elise Tran Huu, Leyssen Pieter, Guéritte Françoise, Litaudon Marc

ResumoTrigocherrin A, a chlorinated - highly oxygenated daphnane diterpenoid orthoester (DDO), was isolated from the bark of Trigonostemon cherrieri. Trigocherrin A is the first example of a naturally occurring halogenated DDO. Its structure was elucidated by comprehensive analysis of NMR spectroscopic data, - its absolute configuration was determined by comparison of experimental - theoretically calculated ECD spectra. Trigocherrin A exhibited a potent - selective effect against Chikungunya virus in Vero cells.

ImprentaOrganic Letters, v. 14, n. 1, p. 342-345, 2012

DescritoresChikungunya virus - Cell ; Chikungunya virus - Molecular structure ; Chikungunya Virus - Virus

Data de Publicação:2012