Trigocherrierin A, a potent inhibitor of Chikungunya virus replication
Autor(es): Bourjot Mélanie, Leyssen Pieter, Neyts Johan, Dumontet Vincent, Litaudon Marc
Resumo: Trigocherrierin A (1) - trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), - six chlorinated analogues, trigocherrins A, B, F - trigocherriolides A-C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- - two-dimensional NMR spectroscopy - through comparison with data reported in the literature. These compounds are potent - selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC?? = 0.6 ± 0.1 µM, SI = 71.7).
Palavras-Chave: Trigonostemon cherrieri; Euphorbiaceae; Chikungunya virus (CHIKV); Daphnane diterpenoid orthoester (DDO)
Imprenta: Molecules, v. 19, n. 3, p. 3617-3627, 2014
Identificador do objeto digital: 10.3390/molecules19033617
Descritores: Chikungunya virus - Molecular structure ; Chikungunya Virus - Virus
Data de publicação: 2014
