Autor(es): Zouache Karima, Fontaine Albin, Vega-Rua Anubis, Mousson Laurence, Thiberge Jean-Michel, Lourenco-De-Oliveira Ricardo, Caro Valérie, Lambrechts Louis, Failloux Anna-Bella

Resumo: Interactions between pathogens - their insect vectors in nature are under the control of both genetic - non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic -/or environmental variability. Evaluating the risk of emergence of arthropod-borne viruses (arboviruses) of public health importance such as chikungunya virus (CHIKV) requires a more realistic appraisal of genetic - environmental contributions to vector competence. In particular, sources of variation do not necessarily act independently - may combine in the form of interactions. Here, we measured CHIKV transmission potential by the mosquito Aedes albopictus in all combinations of six worldwide vector populations, two virus strains - two ambient temperatures (20°C - 28°C). Overall, CHIKV transmission potential by Ae. albopictus strongly depended on the three-way combination of mosquito population, virus strain - temperature. Such genotype-by-genotype-by-environment (G × G × E) interactions question the relevance of vector competence studies conducted with a simpler set of conditions. Our results highlight the need to account for the complex interplay between vectors, pathogens - environmental factors to accurately assess the potential of vector-borne diseases to emerge.

Palavras-Chave: Arbovirus; Chikungunya; Interaction; Mosquito; Temperature; Transmission

Imprenta: Proceedings. Biological Sciences / The Royal Society, v. 281, n. 1792, 2014

Identificador do objeto digital: 10.1098/rspb.2014.1078

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Public health

Data de publicação: 2014