Autor(es): Yusoff Ahmad Faudzi, Mustafa Amal Nasir, Husaain Hani Mat, Hamzah Wan Mansor, Yusof Apandi Mohd, Harun Rozilawati, Abdullah Faezah Noor

Resumo: The aims of the study were to assess the risk factors in relation to cross border activities, exposure to mosquito bite - preventive measures taken.An outbreak of chikungunya virus (CHIKV) infection in Malaysia has been reported in Klang, Selangor (1998) - Bagan Panchor, Perak (2006). In 2009, CHIKV infection re-emerged in some states in Malaysia. It raises the possibilities that re-emergence is part of the epidemics in neighbouring countries or the disease is endemic in Malaysia. For this reason, A community-based case control study was carried out in the state of Kelantan. Prospective case finding was performed from June to December 2009. Those who presented with signs - symptoms of CHIKV infection were investigated. We designed a case control study to assess the risk factors. Assessment consisted of answering questions, undergoing a medical examination, - being tested for the presence of IgM antibodies to CHIKV. Descriptive epidemiological studies were conducted by reviewing both the national surveillance - laboratory data. Multivariable logistic regression analysis was performed to determine risk factors contributing to the illness. Cases were determined by positive to RT-PCR or serological for antibodies by IgM. CHIKV specificity was confirmed by DNA sequencing. There were 129 suspected cases - 176 controls. Among suspected cases, 54.4% were diagnosed to have CHIKV infection. Among the controls, 30.1% were found to be positive to serology for antibodies [IgM, 14.2% - IgG, 15.9%]. For analytic study - based on laboratory case definition, 95 were considered as cases - 123 as controls. Those who were positive to IgG were excluded. CHIKV infection affected all ages - mostly between 50-59 years old. Staying together in the same house with infected patients - working as rubber tappers were at a higher risk of infection. The usage of Mosquito coil insecticide had shown to be a significant protective factor. Most cases were treated as outpatient, only 7.5% needed hospitalization. The CHIKV infection was attributable to central/east African genotype CHIKV. In this study, cross border activity was not a significant risk factor although Thail- - Malaysia shared the same CHIKV genotype during the episode of infections.

Palavras-Chave: Chikungunya; Case-control study; Central/East African genotype; Risk factors

Imprenta: BMC Infectious Diseases, v. 13, p. 211, 2013

Identificador do objeto digital: 10.1186/1471-2334-13-211

Descritores: Chikungunya virus - DNA ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Antibodies ; Chikungunya virus - Serology ; Chikungunya virus - Viral infections ; Chikungunya virus - RT-PCR ; Chikungunya virus - Serology ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2013

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