Autor(es)Yusoff Ahmad Faudzi, Mustafa Amal Nasir, Husaain Hani Mat, Hamzah Wan Mansor, Yusof Apandi Mohd, Harun Rozilawati, Abdullah Faezah Noor

ResumoThe aims of the study were to assess the risk factors in relation to cross border activities, exposure to mosquito bite - preventive measures taken.An outbreak of chikungunya virus (CHIKV) infection in Malaysia has been reported in Klang, Selangor (1998) - Bagan Panchor, Perak (2006). In 2009, CHIKV infection re-emerged in some states in Malaysia. It raises the possibilities that re-emergence is part of the epidemics in neighbouring countries or the disease is endemic in Malaysia. For this reason, A community-based case control study was carried out in the state of Kelantan. Prospective case finding was performed from June to December 2009. Those who presented with signs - symptoms of CHIKV infection were investigated. We designed a case control study to assess the risk factors. Assessment consisted of answering questions, undergoing a medical examination, - being tested for the presence of IgM antibodies to CHIKV. Descriptive epidemiological studies were conducted by reviewing both the national surveillance - laboratory data. Multivariable logistic regression analysis was performed to determine risk factors contributing to the illness. Cases were determined by positive to RT-PCR or serological for antibodies by IgM. CHIKV specificity was confirmed by DNA sequencing. There were 129 suspected cases - 176 controls. Among suspected cases, 54.4% were diagnosed to have CHIKV infection. Among the controls, 30.1% were found to be positive to serology for antibodies [IgM, 14.2% - IgG, 15.9%]. For analytic study - based on laboratory case definition, 95 were considered as cases - 123 as controls. Those who were positive to IgG were excluded. CHIKV infection affected all ages - mostly between 50-59 years old. Staying together in the same house with infected patients - working as rubber tappers were at a higher risk of infection. The usage of Mosquito coil insecticide had shown to be a significant protective factor. Most cases were treated as outpatient, only 7.5% needed hospitalization. The CHIKV infection was attributable to central/east African genotype CHIKV. In this study, cross border activity was not a significant risk factor although Thail- - Malaysia shared the same CHIKV genotype during the episode of infections.

Palavras-ChaveChikungunya; Case-control study; Central/East African genotype; Risk factors

ImprentaBMC Infectious Diseases, v. 13, p. 211, 2013

DescritoresChikungunya virus - DNA ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Antibodies ; Chikungunya virus - Serology ; Chikungunya virus - Viral infections ; Chikungunya virus - RT-PCR ; Chikungunya virus - Serology ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de Publicação:2013