Autor(es): Fokam E B, Levai L D, Guzman H, Amelia P A, Titanji V P K, Tesh R B, Weaver S C

Resumo: To investigate the silent circulation - transmission of arthropod-borne viruses (arboviruses) in the Fako Division of Cameroon. This survey was conducted based on clinical observations - laboratory diagnosis; field collections of mosquitoes. This study was conducted in the Fako Division of South West Cameroon. One hundred - two sera were obtained from febrile patients (with negative laboratory findings for malaria - typhoid fever) at clinics in the Fako Division, - diurnal anthropophilic mosquitoes (4,764) collected. Virus isolation was attempted from these, - sera were screened for antibodies against 18 African arboviruses by haemagglutination inhibition (HI) - complement fixation (CF) tests. No virus was isolated. Fifty three of 79 (67.1%) sera reacted with one or more viral antigens. Twenty nine sera (36.7%) reacted with members of the genus Alphavirus, with Chikungunya (CHIKV) - O'nyong-nyong (ONNV) viruses as the most frequent (34.2%). Forty six sera (58.2%) reacted with members of the genus Flavivirus: 24 (30.4%) were cross-reactive, but 11.4% reacted monotypically with Zika, 5.1% with yellow fever virus (YFV), 5.1% with dengue virus-2 (DENV-2), 2.5% with DENV-1 - 1.3% with Wesselsbron virus, respectively. The plaque reduction neutralisation test used to specify the agent that elicited the response could not resolve 33.3% of the cross reactions between CHIKV - ONNV. Neutralising antibody titres against ONNV - CHIKV were very high indicating probable re-infection. Our results indicate previously undetected circulation of arboviruses in Cameroon, - suggest that they are important, overlooked public health problems.

Imprenta: East African Medical Journal, v. 87, n. 6, p. 262-268, 2010

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health ; Chikungunya virus - Zika fever

Data de publicação: 2010

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