Autor(es)Ochieng Caroline, Ahenda Petronella, Vittor Amy Y, Nyoka Raymond, Gikunju Stella, Wachira Cyrus, Waiboci Lilian, Umuro Mamo, Kim Andrea A, Nderitu Leonard, Juma Bonventure, Montgomery Joel M, Breiman Robert F, Fields Barry

ResumoArthropod-borne viruses are a major constituent of emerging infectious diseases worldwide, but limited data are available on the prevalence, distribution, - risk factors for transmission in Kenya - East Africa. In this study, we used 1,091 HIV-negative blood specimens from the 2007 Kenya AIDS Indicator Survey (KAIS 2007) to test for the presence of IgG antibodies to dengue virus (DENV), chikungunya virus (CHIKV) - Rift Valley fever virus (RVFV).The KAIS 2007 was a national population-based survey conducted by the Government of Kenya to provide comprehensive information needed to address the HIV/AIDS epidemic. Antibody testing for arboviruses was performed on stored blood specimens from KAIS 2007 through a two-step s-wich IgG ELISA using either commercially available kits or CDC-developed assays. Out of the 1,091 samples tested, 210 (19.2%) were positive for IgG antibodies against at least one of the three arboviruses. DENV was the most common of the three viruses tested (12.5% positive), followed by RVFV - CHIKV (4.5% - 0.97%, respectively). For DENV - RVFV, the participant's province of residence was significantly associated (P?.01) with seropositivity. Seroprevalence of DENV - RVFV increased with age, while there was no correlation between province of residence/age - seropositivity for CHIKV. Females had twelve times higher odds of exposure to CHIK as opposed to DENV - RVFV where both males - females had the same odds of exposure. Lack of education was significantly associated with a higher odds of previous infection with either DENV or RVFV (p <0.01). These data show that a number of people are at risk of arbovirus infections depending on their geographic location in Kenya - transmission of these pathogens is greater than previously appreciated. This poses a public health risk, especially for DENV.

ImprentaPloS One, v. 10, n. 7, p. e0132645, 2015

DescritoresChikungunya virus - Arbovirus ; Chikungunya virus - Antibodies ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemic ; Chikungunya virus - Public health

Data de Publicação:2015