Autor(es): Sergon Kibet, Njuguna Charles, Kalani Rosalia, Ofula Victor, Onyango Clayton, Konongoi Limbaso S, Bedno Sheryl, Burke Heather, Dumilla Athman M, Konde Joseph, Njenga M Kariuki, Sang Rosemary, Breiman Robert F

Resumo: An outbreak of Chikungunya virus (CHIKV) disease associated with high fever - severe protracted arthralgias was detected in Lamu, Kenya, peaking in July 2004. At least 1,300 cases were documented. We conducted a seroprevalence study to define the magnitude of transmission on Lamu Isl-. We conducted a systematic cross-sectional survey. We administered questionnaires - tested 288 sera from Lamu residents for IgM - IgG antibodies to CHIKV. Chikungunya virus infection (seropositivity) was defined as a person with IgG -/or IgM antibodies to CHIKV. IgM antibodies to CHIKV were detected in 18% (53/288) - IgG antibodies in 72% (206/288); IgM -/or IgG antibodies were present in 75% (215/288). The seroprevalence findings suggested that the outbreak was widespread, affecting 75% of the Lamu population; extrapolating the findings to the entire population, 13,500 (95% CI, 12,458-14328) were affected. Vector control strategies are needed to control the spread of this mosquito-borne infection.

Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 78, n. 2, p. 333-337, 2008

Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de publicação: 2008