Role of proinflammatory cytokines and chemokines in chronic arthropathy in CHIKV infection
Autor(es): Chaaitanya Itta Krishna, Murugan-am Nagarajan, Sundaram Senthil G, Kawalekar Omkar, Sugunan Attayur P, Manimunda Sathya P, Ghosal Sruti R, Muthumani Karuppiah, Vijayachari Paluru
Resumo: Chikungunya virus (CHIKV) has caused large outbreaks worldwide in recent years. Acute-phase CHIKV infection has been reported to cause mild to severe febrile illness, - in some patients, this may be followed by long-lasting polyarthritis. The mainstay of treatment includes nonsteroidal anti-inflammatory drugs - other disease-modifying agents, the use of which is based on the assumption of an immunological interference mechanism in the pathogenesis. The present study has been designed to generate preliminary evidence to test this hypothesis. The levels of 30 cytokines were estimated in serum samples of acute CHIKV-infected patients, fully-recovered patients, patients with chronic CHIKV arthritis, - controls, using a quantitative multiplex bead ELISA. The levels of the proinflammatory cytokines IL-1 - IL-6 were elevated in acute patients, but IFN-?/? - TNF-? levels remained stable. IL-10, which might have an anti-inflammatory effect, was also elevated, indicating a predominantly anti-inflammatory response in the acute phase of infection. Elevation of MCP-1, IL-6, IL-8, MIP-1?, - MIP-1? was most prominent in the chronic phase. These cytokines - chemokines have been shown to play important roles in other arthritides, including epidemic polyarthritis (EPA) caused by Ross River virus (RRV) - rheumatoid arthritis (RA).The immunopathogenesis of chronic CHIKV arthritis might have similarities to these arthritides. The novel intervention strategies being developed for EPA - RA, such as IL-6 - IL-8 signaling blockade, may also be considered for chronic CHIKV arthritis.
Imprenta: Viral Immunology, v. 24, n. 4, p. 265-271, 2011
Identificador do objeto digital: 10.1089/vim.2010.0123
Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology
Data de publicação: 2011
