Recent introduction and rapid dissemination of Chikungunya virus and Dengue virus serotype 2 associated with human and mosquito coinfections in Gabon, central Africa
Autor(es)Caron Mélanie, Paupy Christophe, Grard Gilda, Becquart Pierre, Mombo Illich, Nso Branly Bikie Bi, Kassa Kassa Fabrice, Nkoghe Dieudonné, Leroy Eric Maurice
ResumoChikungunya virus (CHIKV) - Dengue virus serotype 2 (DENV-2) were recently introduced in central Africa, along with Aedes albopictus. Simultaneous outbreaks of CHIKV - DENV-2 have subsequently occurred, in Cameroon in 2006 - Gabon in 2007. To study the spread of the 2 viruses, we conducted active surveillance of acute febrile syndromes throughout Gabon between 2007 - 2010. Diagnostic methods included quantitative real-time reverse-transcription polymerase chain reaction, - molecular characterization was based on partial envelope gene sequences. Between 2007 - 2010, 4287 acutely febrile patients were investigated for CHIKV - DENV-2 infections, of whom 1567 were CHIKV-positive, 376 DENV-2-positive, - 37 coinfected. We diagnosed 153 CHIKV - 11 DENV-2 cases in 2008, - 5 CHIKV - 9 DENV-2 cases in 2009. In 2010, CHIKV - DENV-2 caused a second large simultaneous outbreak. Among 2826 acutely febrile patients examined during this outbreak, 1112 were CHIKV-positive, 288 DENV-2-positive, - 28 coinfected. Mosquitoes were collected near the homes of coinfected patients, - 1 Aedes albopictus specimen was found to be positive for both CHIKV - DENV-2. These findings show the rapid dissemination of CHIKV - DENV-2 within a nonimmune population in a tropical African country, probably facilitated by the spread of Aedes albopictus. This has resulted in major simultaneous outbreaks with numerous coinfections in both human - mosquito.
ImprentaClinical Infectious Diseases, v. 55, n. 6, p. e45-e53, 2012
Identificador do Objeto Digital10.1093/cid/cis530
DescritoresChikungunya virus - Biochemistry ; Chikungunya virus - DNA ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Viral infections ; Chikungunya virus - Molecular methods ; Chikungunya virus - Real Time PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de Publicação:2012
