Outbreak of chikungunya on Reunion Island: Early clinical and laboratory features in 157 adult patients
Autor(es): Borgherini Gianandrea, Poubeau Patrice, Staikowsky Frederik, Lory Manuella, Le Moullec Nathalie, Becquart Jean Philippe, Wengling Catherine, Michault Alain, Paganin Fabrice
Resumo: Chikungunya is a reemerging disease. In 2005-2006, a severe outbreak occurred on Reunion Isl- in the southwestern part of the Indian Ocean. Other isl-s in this area were affected during the same period. Adult patients with acute chikungunya (defined as onset of fever -/or polyarthralgia in the 5 days preceding consultation) - laboratory-confirmed chikungunya who were referred to Groupe Hospitalier Sud Reunion during the period from March 2005 through April 2006 were included in this retrospective study. Their clinical - laboratory features are reported. Laboratory-confirmed acute chikungunya was documented in 157 patients. The mean age of patients was 57.9 years, - the ratio of male to female patients was 1.24 : 1. Sixty percent of patients had at least 1 comorbidity. Ninety-seven patients (61.8%) were hospitalized, - 60 (38.2%) were treated as outpatients. Five fatalities were reported. One hundred fifty-one patients (96.1%) experienced polyarthralgia, - 129 (89%) experienced fever. Gastrointestinal symptoms were reported by 74 patients (47.1%), - skin rash was reported by 63 (40.1%). Hemorrhagic signs were rare. Lymphopenia - hypocalcemia were the prominent laboratory findings. Severe thrombocytopenia was rarely observed. Chikungunya virus can be responsible for explosive outbreaks of disease. Polyarthralgia - fever are the 2 main clinical features. In this era of travel - globalization, chikungunya should be considered in the differential diagnosis of febrile polyarthralgia with an abrupt onset.
Imprenta: Clinical Infectious Diseases, v. 44, n. 11, p. 1401-1407, 2007
Identificador do objeto digital: 10.1086/517537
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2007
