On chikungunya acute infection and chloroquine treatment
Autor(es): De Lamballerie Xavier, Boisson Véronique, Reynier Jean-Charles, Enault Sébastien, Charrel Rémi N, Flahault Antoine, Roques Pierre, Le Grand Roger
Resumo: In recent issues, the efficacy of chloroquine (- the dosage that may be used) in the treatment of acute chikungunya infections was discussed. We have conducted a double-blind placebo-controlled r-omized trial on the French Reunion Isl- (Indian Ocean), in which 27 patients received chloroquine - 27 patients received a placebo treatment. The chloroquine treatment consisted of 600 mg at day 1, 600 mg at days 2 - 3, - 300 mg at days 4 - 5. No significant difference between groups could be identified regarding the duration of febrile arthralgia or the decrease of viremia between day 1 - day 3. However, at day 200, patients who received chloroquine complained more frequently of arthralgia than those who received placebo (p < 0.01). In conclusion, our results suggest that there is currently no justification for the use of chloroquine to treat acute chikungunya infections.
Imprenta: Vector Borne and Zoonotic Diseases, v. 8, n. 6, p. 837-839, 2008
Identificador do objeto digital: 10.1089/vbz.2008.0049
Descritores: Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Public health
Data de publicação: 2008
