Autor(es): Garcia Alexis, Diego Lema, Judith Barroso

Resumo: Chikungunya virus (CHIKV) is a mosquito-borne human pathogen that affects millions of individuals each year by causing non-specific flu-like symptoms, with a characteristic rash accompanied by joint pain that may last for a long time after the resolution of the infection. Despite intense research efforts, no approved vaccine or antiviral therapy is yet available. This review is based on articles retrieved by PubMed - clinical trials since 1980 to present. Virus complexity, protective - non-protective immune responses against the virus, - the most important a new patented approaches for Chikungunya vaccine development are discussed.

Palavras-Chave: Chikungunya virus; DNA vaccines; Immune response; Vaccines; Virus particles; Viral vectors

Imprenta: Recent Patents on Inflammation & Allergy Drug Discovery, v. 9, n. 1, p. 31-37, 2015

Identificador do objeto digital: 10.2174/1872213X09666150223114226

Descritores: Chikungunya virus - DNA ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Immunology

Data de publicação: 2015