Molecular mechanisms involved in the pathogenesis of alphavirus-induced arthritis
Autor(es): Assunção-Miranda Iranaia, Cruz-Oliveira Christine, Da Poian Andrea T
Resumo: Arthritogenic alphaviruses, including Ross River virus (RRV), Chikungunya virus (CHIKV), Sindbis virus (SINV), Mayaro virus (MAYV), O'nyong-nyong virus (ONNV), - Barmah Forest virus (BFV), cause incapacitating - long lasting articular disease/myalgia. Outbreaks of viral arthritis - the global distribution of these diseases point to the emergence of arthritogenic alphaviruses as an important public health problem. This review discusses the molecular mechanisms involved in alphavirus-induced arthritis, exploring the recent data obtained with in vitro systems - in vivo studies using animal models - samples from patients. The factors associated to the extension - persistence of symptoms are highlighted, focusing on (a) virus replication in target cells, - tissues, including macrophages - muscle cells; (b) the inflammatory - immune responses with recruitment - activation of macrophage, NK cells - T lymphocytes to the lesion focus - the increase of inflammatory mediators levels; - (c) the persistence of virus or viral products in joint - muscle tissues. We also discuss the importance of the establishment of novel animal models to test new molecular targets - to develop more efficient - selective drugs to treat these diseases.
Imprenta: BioMed Research International, v. 2013, p. 973516, 2013
Identificador do objeto digital: 10.1155/2013/973516
Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Infectious diseases ; Chikungunya virus - T lymphocytes ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Molecular screening ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2013
