Interferon system in cells from human tumors and from persons predisposed to cancer
Autor(es): Worthington M, Aaronson S A
Resumo: In the present study, the interferon system was evaluated in fibroblasts from persons predisposed to leukemia or other cancers, in fibroblasts from persons with neoplastic disease, - in human tumor cells. Of 31 normal fibroblast strains from patients with tumors or diseases associated with a high incidence of malignancy, only one cell strain had a poor response to either of the two interferon inducers used, polyinosinic-polycytidylic acid - Chikungunya virus. On the other h-, cell cultures of five human tumors were much less sensitive to the antiviral effect of these interferon inducers - of human interferon - produced less interferon in response to Chikungunya virus than any of the nontumor tissues studied.
Imprenta: Infection and Immunity, v. 3, n. 3, p. 424-428, 1971
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus
Data de publicação: 1971
