Hemorrhagic disease in rodents caused by Chikungunya virus. 1. Studies of hemostasis
Autor(es): Weiss H J, Halstead S B, Russ S B
Resumo: Suckling mice and rats develop a hemorrhagic syndrome when infected with a low mouse passage strain of Thailand chikungunya virus. Studies of hemostasis revealed thrombocytopenia, prolonged bleeding time, prolonged clotting time and decrease in prothrombin time and factor V and factors VII + X. Attempts to modify the occurrence of hemorrhage by pretreatment with corticosteroids or antibiotics were unsuccessful. Animals treated with heparin appeared to be somewhat protected against hemorrhage but not death.
Imprenta: Proceedings of the Society for Experimental Biology and Medicine, v. 119, p. 427-432, 1965
Identificador do objeto digital: 10.3181/00379727-119-30201
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Proteins ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus
Data de publicação: 1965
