Evidence for endemic Chikungunya virus infections in Bandung, Indonesia
Autor(es): Kosasih Herman, de Mast Quirijn, Widjaja Susana, Sudjana Primal, Antonjaya Ungke, Ma'roef Chairin, Riswari Silvita Fitri, Porter Kevin R, Burgess Timothy H, Alisjahbana Bachti, van der Ven Andre, Williams Maya
Resumo: Chikungunya virus (CHIKV) is known to cause sporadic or explosive outbreaks. However, little is known about the endemic transmission of CHIKV. To ascertain the endemic occurrence of CHIKV transmission, we tested blood samples from patients with a non-dengue febrile illness who participated in a prospective cohort study of factory workers in B-ung, Indonesia. From August 2000 to June 2004, - September 2006 to April 2008, 1901 febrile episodes occurred - 231 (12.2%) dengue cases were identified. The remaining febrile cases were evaluated for possible CHIKV infection by measuring anti-CHIKV IgM - IgG antibodies in acute - convalescent samples. Acute samples of serologically positive cases were subsequently tested for the presence of CHIKV RNA by RT-PCR -/or virus isolation. A total of 135 (7.1%) CHIKV infections were identified, providing an incidence rate of 10.1/1,000 person years. CHIKV infections were identified all year round - tended to increase during the rainy season (January to March). Severe illness was not found - severe arthralgia was not a prominently reported symptom. Serial post-illness samples from nine cases were tested to obtain a kinetic picture of IgM - IgG anti-CHIKV antibodies. Anti-CHIKV IgM antibodies were persistently detected in high titers for approximately one year. Three patients demonstrated evidence of possible sequential CHIKV infections. The high incidence rate - continuous chikungunya cases in this adult cohort suggests that CHIKV is endemically transmitted in B-ung. Further characterization of the circulating strains - surveillance in larger areas are needed to better underst- CHIKV epidemiology in Indonesia.
Imprenta: PLoS Neglected Tropical Diseases, v. 7, n. 10, p. e2483, 2013
Identificador do objeto digital: 10.1371/journal.pntd.0002483
Descritores: Chikungunya virus - DNA ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya virus - RT-PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2013
