Autor(es): Glasgow L A, Odugbemi T, Dwyer P, Ritterson A L

Resumo: Eperythrozoon coccoides is a common blood parasite of rodents - the etiological agent of a chronic infection present in many mouse colonies. After primary infection, mice develop a parasitemia - anemia followed by a chronic, latent infection. During the acute phase of infection, mice manifest a striking suppression of interferon production in response to induction with Newcastle disease virus, Chikungunya virus, - poly I:C. These data suggest that the reticuloendothelial system involvement with this agent is associated with impairment of the interferon response. The enhanced susceptibility of E. coccoides-infected animals to certain viral infections may be related to this suppression of interferon production.

Imprenta: Infection and Immunity, v. 4, n. 4, p. 425-430, 1971

Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya virus - Clinical examination ; Chikungunya Virus - Virus

Data de publicação: 1971

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