Emergence and clinical insights into the pathology of Chikungunya virus infection
Autor(es): Jaffar-B-jee Marie Christine, Ramful Duksha, Gauzere Bernard Alex, Hoarau Jean Jacques, Krejbich-Trotot Pascale, Robin Stephanie, Ribera Anne, Selambarom Jimmy, Gasque Philippe
Resumo: Major epidemics of Chikungunya have re-emerged with millions of cases worldwide. What was once largely a tropical disease in poorer countries is now recognized as a major global health issue. The disease is perpetuated by the alphavirus Chikungunya, - is transmitted by Aedes mosquitoes. The infection is highly symptomatic, with fever, skin rash - incapacitating arthralgia, which can evolve to chronic arthritis - rheumatism in elderly patients. Mother-to-child transmission, encephalitis, Guillain-Barré syndrome - deaths have been noted. In this article, we will highlight the epidemiological, clinical, virological - immunological aspects of the disease - mention the therapies that have been used during recent epidemics. Novel prevention measures to control the mosquito - a new vaccine are highly warranted.
Palavras-Chave: Anti-TNF-?; Arthritis; Chikungunya; Chloroquine; Encephalitis; Immunology; Methotrexate; Mosquito; Neutralizing antiserum; Vaccine
Imprenta: Expert review of anti-infective therapy, v. 8, n. 9, p. 987-996, 2010
Identificador do objeto digital: 10.1586/eri.10.92
Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2010
