Differential infectivities of o'nyong-nyong and Chikungunya virus isolates in Anopheles gambiae and Aedes aegypti mosquitoes
Autor(es): Vanlandingham Dana L, Hong Chao, Klingler Kimberly, Tsetsarkin Konstantin, McElroy Kate L, Powers Ann M, Lehane Michael J, Higgs Stephen
Resumo: O'nyong-nyong virus (ONNV) - chikungunya virus (CHIKV) are closely related alphaviruses that cause human disease in Africa - Asia. Like most alphaviruses, CHIKV is vectored by culicine mosquitoes. ONNV is considered unusual as it primarily infects anopheline mosquitoes; however, there are relatively few experimental data to support this. In this study, three strains of ONNV - one strain of CHIKV were evaluated in Anopheles gambiae - Aedes aegypti mosquitoes - in four cell lines. As predicted, CHIKV was not infectious to An. gambiae, - we observed strain-variability for ONNV with respect to the ability of the virus to infect An. gambiae - Ae. aegypti. The species specificity in vivo was reflected by in vitro experiments using culicine - anopheline-derived cell lines.
Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 72, n. 5, p. 616-621, 2005
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya Virus - Virus
Data de publicação: 2005
