Autor(es): Kashyap Rajpal Singh, Morey Shweta, Bhullar Shradha, Baheti Neeraj, Chandak Nitin, Purohit Hemant, Taori Girdhar, Daginawala Hatim

Resumo: Chikungunya infection caused by Chikungunya virus (CHIKV) is an inflammatory disease affecting the joints - may also lead to neurological complications. We investigated a panel of human Toll-like receptor (TLR)-induced cytokines in Chikungunya patients with - without neurological complications. In a case-control study, a panel of 12 cytokines - chemokines, TNF-?, IFN-?, IL-1?, IL-6, IL-12, IL-17A, IL-8, monocyte chemotactic protein (MCP)-1, RANTES, interferon (IFN)-?-induced protein (IP)-10, monokine induced by IFN-? (MIG) - thymus - activation-regulated chemokine (TARC), was analysed using a conventional ELISA protocol in the serum samples of Chikungunya patients without neurological complications - in the cerebrospinal fluid (CSF) - paired serum samples of Chikungunya patients with neurological complications. The levels of 3 cytokines, IL-1?, IL-17A - IL-8, - 4 chemokines, MCP-1, RANTES, IP-10 - TARC, were raised in serum samples of Chikungunya patients without neurological complications, whereas, 4 cytokines, TNF-?, IFN-?, IL-6 - IL-8, - 4 chemokines, MCP-1, RANTES, MIG - TARC, were elevated in CSF samples of Chikungunya patients with neurological complications. Moreover, the levels of IL-6 - IL-8 cytokines were significantly elevated in the CSF compared to paired serum samples in Chikungunya patients with neurological complications. In CHIKV infection, multiple cytokines are elevated in serum - CSF. The elevation in IL-6 - IL-8 cytokines in CSF correlates with neurological involvement.

Imprenta: Neuroimmunomodulation, v. 21, n. 6, p. 338-346, 2014

Identificador do objeto digital: 10.1159/000358240

Descritores: Chikungunya virus - Biochemistry ; Chikungunya virus - Biosynthesis ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology

Data de publicação: 2014