Cutting edge: Independent roles for IRF-3 - IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection
Autor(es): Schilte Clémentine, Buckwalter Matthew R, Laird Melissa E, Diamond Michael S, Schwartz Olivier, Albert Matthew L
Resumo: The host response to Chikungunya virus is dependent on the direct action of type I IFN on infected nonhematopoietic cells. Prior studies have demonstrated that multiple host sensors coordinate an antiviral response; however, the tissue source(s) - signaling pathways for IFN production remain unknown. In this study, we demonstrate that IRF-3 - IRF-7 are functionally redundant, but lack of both factors results in lethal infection in adult mice. Reciprocal bone marrow chimeras indicated that IRF-3 or IRF-7 expression in either hematopoietic or nonhemotopoietic cell compartments was capable of inducing an antiviral response. Interestingly, redundancy of IRF-3 - IRF-7 was age dependent, as neonatal animals lacking either factor succumbed to infection. We further demonstrate that IPS-1 is essential in nonhematopoietic cells - preferentially required during early life. These results highlight the interplay between nonimmune - immune cells during Chikungunya virus infection - suggest an important role for nonhematopoietic cells as a critical source of IFN-?/?.
Imprenta: Journal of Immunology, v. 188, n. 7, p. 2967-2971, 2012
Identificador do objeto digital: 10.4049/jimmunol.1103185
Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Protein synthesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Immune response ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2012
