Comparative production of interferon by foreskin fibroblasts from newborn infants - children.
Autor(es): St Geme J W, Horrigan D S
Resumo: Primary fibroblastic cells were cultivated from the foreskins of newborn infants and children, 4 to 10 years of age. The fibroblasts were infected with chikungunya virus, and the cultures were harvested at 48 hours for assay of interferon. Foreskin fibroblasts from the older child produced four- to eight-fold more interferon than neonatal fibroblasts. This observation supports the previously recognized diminution of interferon response of the infected mouse and documents for the first time that the human neonatal cell is similarly insufficient.
Imprenta: The Journal of Laboratory and Clinical Medicine, v. 74, n. 6, p. 946-949, 1969
Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya Virus - Virus ; Chikungunya virus - Public health
Data de publicação: 1969
