Clinical and radiological features of imported chikungunya fever in Japan: A study of six cases at the National Center for Global Health and Medicine
Autor(es): Mizuno Yasutaka, Kato Yasuyuki, Takeshita Nozomi, Ujiie Mugen, Kobayashi Taiichiro, Kanagawa Shuzo, Kudo Koichiro, Lim Chang-Kweng, Takasaki Tomohiko
Resumo: Chikungunya fever (CHIKF) is currently distributed in Africa - in South - Southeast Asia; outbreaks have occurred periodically in the region over the past 50 years. After a large outbreak had occurred in countries in the western Indian Ocean region in 2005, several countries reported cases of CHIKF from travelers who had visited affected areas. In Japan, there have been only 15 cases of CHIKF patients so far, according to the National Institute of Infectious Diseases. Therefore, to evaluate the clinical - radiological features associated with the disease, we describe 6 imported cases of CHIKF. All of the patients had had prolonged arthralgia on admission to our hospital, - diagnosis was confirmed with specific antibodies by using an IgM-capture enzyme-linked immunoassay - a plaque reduction neutralizing antibody assay. Magnetic resonance imaging (MRI) of one patient revealed erosive arthritis - tenosynovitis during the convalescence stage. Clinicians should be aware of the late consequences of infection by the chikungunya virus (CHIKV) - recognize the possible association of subacute - chronic arthritis features. In addition, competent vectors of CHIKV, Aedes aegypti, can now be found in many temperate areas of the eastern - western hemispheres, including Japan. This fact raises concern that the virus could be introduced - become established in these areas. This necessitates an increased awareness of the disease, because imported cases are likely to contribute to the spread of CHIKV infection wherever the competent mosquito vectors are distributed.
Imprenta: Journal of Infection and Chemotherapy, v. 17, n. 3, p. 419-423, 2011
Identificador do objeto digital: 10.1007/s10156-010-0124-y
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Antibodies ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology
Data de publicação: 2011
