Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy
Autor(es): Joubert Pierre-Emmanuel, Werneke Scott, de la Calle Claire, Guivel-Benhassine Florence, Giodini Alessandra, Peduto Lucie, Levine Beth, Schwartz Olivier, Lenschow Deborah, Albert Matthew L
Resumo: It has been recognized that macroautophagy constitutes an important survival mechanism that allows both the maintenance of cellular homeostasis - the regulation of programmed cell death pathways (e.g., apoptosis). Although several pathogens have been described to induce autophagy, the prosurvival function of this process in infectious models remains poorly characterized. Our recent studies on chikungunya virus (CHIKV), the causative agent of major epidemics in India, Southeast Asia - southern Europe, reveal a novel mechanism by which autophagy limits the cytopathic effects of CHIKV by impinging upon virus-induced cell death pathways.
Imprenta: Autophagy, v. 8, n. 8, p. 1261-1263, 2012
Identificador do objeto digital: 10.4161/auto.20751
Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic
Data de publicação: 2012
