Autor(es): Simon Fabrice, Javelle Emilie, Oliver Manuela, Leparc-Goffart Isabelle, Marimoutou Catherine

Resumo: Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti - Aedes albopictus. After half a century of focal outbreaks of acute febrile polyarthralgia in Africa - Asia, the disease unexpectedly spread in the past decade with large outbreaks in Africa - around the Indian Ocean - rare autochthonous transmission in temperate areas. This emergence brought new insights on its pathogenesis, notably the role of the A226V mutation that improved CHIKV fitness in Ae. albopictus - the possible CHIKV persistence in deep tissue sanctuaries for months after infection. Massive outbreaks also revealed new aspects of the acute stage: the high number of symptomatic cases, unexpected complications, mother-to-child transmission, - low lethality in debilitated patients. The follow-up of patients in epidemic areas has identified frequent, long-lasting, rheumatic disorders, including rare inflammatory joint destruction, - common chronic mood changes associated with quality-of-life impairment. Thus, the globalization of CHIKV exposes countries with Aedes mosquitoes both to brutal outbreaks of acute incapacitating episodes - endemic long-lasting disorders.

Palavras-Chave: Chikungunya; Alphavirus; Rheumatism; Emergence; Chronicity

Imprenta: Current Infectious Disease Reports, v. 13, n. 3, p. 218-228, 2011

Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Epidemic

Data de publicação: 2011

INDICADORES

ACESSO