Autor(es): Bhakat Soumendranath, Soliman Mahmoud E S

Resumo: Chikungunya virus (CHIKV) is one of the re-emerging neglected" tropical diseases whose recent outbreak affected not only Africa - South-East Asia but also several parts of America - Europe. To date, despite its serious nature, no antivirals or vaccines were developed in order to counter this resurgent infectious disease. The recent advancement in crystallography - availability of crystal structures of certain domains of CHIKV initiates the development of anti-CHIKV agents using structure-based drug design or synthetic medicinal chemistry approach. Despite the fact that almost 50% of the new chemical entities against several biological targets were either obtained from natural products or natural product analogues, a very humble effort was directed towards identification of novel CHIKV inhibitors from natural products. In this review, besides a brief overview on CHIKV as well as the nature as a source of medicines, we highlight the current progress - future steps towards the discovery of CHIKV inhibitors from natural products. This report could pave the road towards the design of novel semi-synthetic derivatives with enhanced anti-viral activities."

Palavras-Chave: Chikungunya virus; Antivirals; Natural product

Imprenta: Journal of Natural Medicines, v. 69, n. 4, p. 451-462, 2015

Identificador do Objeto Digital: 10.1007/s11418-015-0910-z

Descritores: Chikungunya virus - Molecular structure ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever

Data de Publicação: 2015