Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
Autor(es): Labadie Karine, Larcher Thibaut, Joubert Christophe, Mannioui Abdelkrim, Delache Benoit, Brochard Patricia, Guig- Lydie, Dubreil Laurence, Lebon Pierre, Verrier Bernard, de Lamballerie Xavier, Suhrbier Andreas, Cherel Yan, Le Grand Roger, Roques Pierre
Resumo: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, - pain in muscles - joints. The recent emergence or reemergence of CHIKV in the Indian Ocean Isl-s - India has stressed the need to better underst- the pathogenesis of this disease. Previous CHIKV disease models have used young or immunodeficient mice, but these do not recapitulate human disease patterns - are unsuitable for testing immune-based therapies. Herein, we describe what we believe to be a new model for CHIKV infection in adult, immunocompetent cynomolgus macaques. CHIKV infection in these animals recapitulated the viral, clinical, - pathological features observed in human disease. In the macaques, long-term CHIKV infection was observed in joints, muscles, lymphoid organs, - liver, which could explain the long-lasting CHIKV disease symptoms observed in humans. In addition, the study identified macrophages as the main cellular reservoirs during the late stages of CHIKV infection in vivo. This model of CHIKV physiopathology should allow the development of new therapeutic -/or prophylactic strategies.
Imprenta: The Journal of Clinical Investigation, v. 120, n. 3, p. 894-906, 2010
Identificador do objeto digital: 10.1172/JCI40104
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever
Data de publicação: 2010
