Cellular and molecular mechanisms of chikungunya pathogenesis

Autor(es): Lum Fok-Moon, Ng Lisa F P


Resumo: Chikungunya virus (CHIKV) is an arthropod-borne virus that causes chikungunya fever, a disease characterized by the onset of fever - rashes, with arthralgia as its hallmark symptom. CHIKV has re-emerged over the past decade, causing numerous outbreaks around the world. Since late 2013, CHIKV has reached the shores of the Americas, causing more than a million cases of infection. Despite concentrated efforts to underst- the pathogenesis of the disease, further outbreaks remain a threat. This review highlights important findings regarding CHIKV-associated immunopathogenesis - offers important insights into future directions. This article forms part of a symposium in Antiviral Research on Chikungunya discovers the New World.""


Palavras-Chave: Chikungunya virus; Immune response; Immunopathogenesis; Pathology


Imprenta: Antiviral Research, v. 120, p. 165-174, 2015


Identificador do objeto digital: 10.1016/j.antiviral.2015.06.009


Descritores: Chikungunya virus - Biochemistry ; Chikungunya virus - Cytopathology ; Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Immune response ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Molecular screening ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology


Data de publicação: 2015