Arthritogenic alphaviruses: new insights into arthritis and bone pathology
Autor(es): Chen Weiqiang, Foo Suan-Sin, Sims Natalie A, Herrero Lara J, Walsh Nicole C, Mahalingam Suresh
Resumo: Arthritogenic alphaviral infection begins as a febrile illness - often progresses to joint pain - rheumatic symptoms that are described as polyarthritis. Alphaviral arthritis - classical arthritides share many similar cellular - immune mediators involved in their pathogenesis. Recent in vitro - in vivo evidence suggests that bone loss resulting from increased expression of bone resorption mediators may accompany alphaviral infection. In addition, several longitudinal studies have reported more severe - delayed recovery of alphaviral disease in patients with pre-existing arthritic conditions. This review aims to provide insights into alphavirus-induced bone loss - focuses on aspects of disease exacerbation in patients with underlying arthritis - on possible therapeutic targets.
Palavras-Chave: Ross River virus; Alphavirus; Arthritis; Bone loss; Chikungunya virus; Inflammation
Imprenta: Trends in Microbiology, v. 23, n. 1, p. 35-43, 2015
Identificador do objeto digital: 10.1016/j.tim.2014.09.005
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Inflammation ; Chikungunya Virus - Virus ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2015
