Alphavirus RNA synthesis and non-structural protein functions
Autor(es): Rupp Jonathan C, Sokoloski Kevin J, Gebhart Natasha N, Hardy Richard W
Resumo: The members of the genus Alphavirus are positive-sense RNA viruses, which are predominantly transmitted to vertebrates by a mosquito vector. Alphavirus disease in humans can be severely debilitating, - depending on the particular viral species, infection may result in encephalitis - possibly death. In recent years, alphaviruses have received significant attention from public health authorities as a consequence of the dramatic emergence of chikungunya virus in the Indian Ocean isl-s - the Caribbean. Currently, no safe, approved or effective vaccine or antiviral intervention exists for human alphavirus infection. The molecular biology of alphavirus RNA synthesis has been well studied in a few species of the genus - represents a general target for antiviral drug development. This review describes what is currently understood about the regulation of alphavirus RNA synthesis, the roles of the viral non-structural proteins in this process - the functions of cis-acting RNA elements in replication, - points to open questions within the field.
Imprenta: The Journal of General Virology, v. 96, n. 9, p. 2483-2500, 2015
Identificador do objeto digital: 10.1099/jgv.0.000249
Descritores: Chikungunya virus - Protein synthesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Public health
Data de publicação: 2015
