Synthesis and bio-evaluation of aryl hydrazono esters for oviposition responses in Aedes albopictus
Autor(es): Bandyopadhyay, Prabal; Guha, Lopamudra; Seenivasagan, T.; Sathe, Manisha; Sharma, Pratibha; Parashar, B. D.; Kaushik, M. P.
Resumo: A novel series of aryl hydrazono esters (AHE) (1-13) were synthesized (yield 76-98%) to study the oviposition responses in Aedes albopictus (Skuse) mosquitoes for the first time. At a concentration of 10 mu g ml super(-1) in dual choice experiment, among the screened compounds, AHE-12 showed remarkable oviposition attractant activity with an oviposition activity index (OAI) of +0.299 (greater than 95% confidence limit) comparable to p-cresol (OAI +0.320) which is well-reported oviposition attractant for Aedes aegypti. Conversely, AHE-10 exhibited highest oviposition deterrent activity with OAI -0.247. The possible utilization of these compounds will be in integrated vector management strategies.
Palavras-Chave: Aryl hydrazono ester; Oviposition; Aedes albopictus; Dengue; Chikungunya
Imprenta: Bioorganic and Medicinal Chemistry Letters, v. 21, n. 2, p. 794-797, 2011.
Descritores: Aedes aegypti - Dengue
Data de publicação: 2011
