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Immunotoxicity activity of 1,2,4-Trimethoxybenzene from the Paulownia coreana Uyeki. against Aedes aegypti L

Autor(es)Chung, I. M.; Moon, H. I.
ResumoThe flower parts of Paulownia coreana were extracted and the major essential oils composition and immunotoxicity effects were studied. The analyses were conducted by gas chromatography-mass spectroscopy (GC-MS) revealed that the essential oils of P. coreana. The P. coreana essential oil (PCEO) yield was 0.175%, and GC/MS analysis revealed that its major constituents were benzyl alcohol (13.72%), phenol, 3,4-dimethoxy-methyl ester (3.64%), phenol, 2-methoxy-3-(2-popenyl)-methyl ester (6.24%), 1,2,4-Trimethoxybenzene (8.32%), tricosane (3.28%), and pentacosane (3.26%). The essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC sub(50) value of 31.64 ppm and an LC sub(90) value of 56.43 ppm. 1,2,4-Trimethoxybenzene was the most toxic among the major components with an LC sub(50) value near 23.1 ppm. The results could be useful in search for newer, safer, and more effective natural immunotoxicity agents against A. aegypti.
Palavras-ChaveAedes aegypti L; Paulownia coreana; Essential oils; Immunotoxicity effects
ImprentaImmunopharmacology and Immunotoxicology, v. 33, n. 1, p. 97-99, 2011.
DescritoresAedes aegypti - Immune response ; Aedes aegypti - Immunology
Data de Publicação:2011